1. 3D skin printing

It sounds like science fiction, but Sunnybrook researchers have developed a machine that produces human-like skin to treat burns. A handheld version of the skin printer was unveiled this year; one day, physicians may be able to print skin directly onto a patient’s wound at the bedside.

2. Stem cell and tissue engineering

This newly published study (in November 2018) found that skin discarded during burn surgery has useable stem cells. With human trials beginning in early 2019, this discovery could be ground-breaking for burn patients at Sunnybrook and across the country.

3. Hypermetabolism

A Sunnybrook study found the behaviour of fat in the body fundamentally changes after a severe burn. This state of hypermetabolism causes an increase in energy expenditure and insulin resistance in the patient, and the resulting complications can be fatal.

4. Sunnybrook Protocol for treatment of SJS/TENS

A team of Sunnybrook specialists developed the Sunnybrook Protocol for SJS/TENS. It’s the first Canadian protocol for dealing with the disease, which happens when the immune system attacks the outer layers of skin, the eyes, genitals, throat and lips, similar to flesh-eating disease. Of the 300 patients treated every year at the Ross Tilley Burn Centre – the largest burn centre in Canada – up to 10 are admitted with SJS/TENS.

5.  Reducing blood loss

This study found that a modified surgical technique significantly reduced the number of blood transfusions needed by burn patients.

6. Formation of the Canadian Burn Association

After hosting several successful burn symposiums, Sunnybrook played an integral role in the development of the recently created Canadian Burn Association.

7. Glucose control

This Sunnybrook-led study found that patients with good glucose control had a lower incidence of infection, sepsis and death compared with patients with poor glucose control. It also found that patients with good glucose control had milder inflammatory and hypermetabolic responses.

8. Ventilation modes

High-frequency oscillatory ventilation (HFOV) is an unconventional ventilation strategy in burn patients. However, this Sunnybrook study found that it played a useful role in the supportive management of burn patients with severe oxygenation failure, unresponsive to conventional ventilation. Importantly, HFOV allowed surgery to proceed in patients who may have otherwise been too unstable to go to the operating room.

9. Use of albumin in burns

This review article examines the use of human albumin (HA), the most abundant protein in human blood plasma, in burn treatment.

The post Highlights from 20 years of burn research appeared first on Your Health Matters.

[toggle title=”Click here to view a plain-text version of the infographic”]

Skin discarded during burn surgery has useable stem cells: Sunnybrook study

November 5, 2018: The Future of Burn Care.

For a long time, burned skin tissue has been considered to be nothing more than medical waste.

Now, Sunnybrook researchers have found in a pre-clinical study that debrided burned skin, which is routinely removed from patients during surgery and discarded,  contains viable, undamaged cells that show characteristics of mesenchymal skin stem cells (MSCs).

These cells can be extracted, characterized, expanded, and incorporated into skin substitutes to promote wound healing.

Why is finding new ways to heal wounds so important?

Worldwide, 11 million people are burned and 265,000 people die from burn injuries every year.

The larger the burn, the less healthy skin remains for skin grafting . More alternative wound coverage materials are needed, because current materials are either ineffective, cause immunologic rejections, take too long to produce sufficient cell numbers or are too expensive.

The study

1. Burned skin tissue debrided during surgery.
2. Tissue added to sterile containers, carefully wrapped and transferred to research lab.
3. Cells extracted and cultured. Later stored in liquid nitrogen.
4. When cells began to grow out from the tissue, the tissue was removed, and adherent cells continued to grow.

5. Applied the cellular coverage material onto excisional wounds. Found that BD-MSCs facilitates healing and decreases healing time

Burn-derived stem cells are a promising new source of skin stem cells for regenerative medicine and burn-wound management.

Without being limited by the common obstacles of stem cell therapies and its availability, this method could revolutionize the way we treat burn patients, and potentially patients with complex wounds.

Authors: Saeid Amini-Nik, M.D., Ph.D.; Reinhard Dolp; Gertraud Eylert,; Andrea K Datu; Alexandra Parousis; Camille Blakeley; Marc G Jeschke

Published in EBioMedicine Journal on November 5, 2018.

Funding: Canadian Institutes of Health Research # 123336; CFI Leader’s Opportunity Fund: Project # 25407; National Institutes of Health 2R01GM087285-05A1; EMHSeed: Fund: 500463; A generous donation from Toronto Hydro; Integra©Life Science Company provided the meshed bilayer Integra© for porcine experiments

[/toggle]

More on this topic

Engineering a handheld 3-D skin printer to heal burn wounds

The post Skin discarded during burn surgery has useable stem cells: study appeared first on Your Health Matters.